The invention relates to a dihydropyridine microemulsion preparation with grain diameter of between 1 and 100nm, which consists of the following raw materials in percentage by weight: 0.1 to 1.5 percent of dihydropyridine, 17.0 to 30.9 percent of surfactant, 11.4 to 20.6 percent of cosurfactant, 3.4 to 5.2 percent of oil, and the balance of distilled water. The microemulsion preparation is of an oil-in-water type, and has clear, transparent and uniform appearance and high stability. The microemulsion preparation has the advantages of safety, high efficiency and sustained release, simple preparation process, low production cost and the like, can be produced in scale without special equipment, and has excellent market prospect.