利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN102584943A 一种血管平滑肌L型钙离子通道免疫原性肽段及其用途 无效 - 撤回

一种血管平滑肌L型钙离子通道免疫原性肽段及其用途
摘要：
一种血管平滑肌L型钙离子通道免疫原性肽段及其用途，属于生物技术和医药领域。所述的免疫原性肽段具有如下的氨基酸序列：CGGPAEEDPS、CPAEEDPS、PAEEDPSGGC或PAEEDPSC，优选CPAEEDPS。将包含第一连接位点的血管平滑肌L型钙离子通道免疫原性肽段与一种或多种载体、优选地与重组Qβ-2aa噬菌体病毒样颗粒蛋白耦联结合，以形成有序、重复的多肽-载体疫苗。公开了该疫苗在治疗原发性高血压方面的应用，该疫苗能够产生高效的特异性的抗血管平滑肌L型钙离子通道免疫原性肽段的抗体，该抗体可以有效阻断L型钙离子通道，能够显著降低自发性高血压大鼠的血压。
摘要（英）：

The invention discloses a vascular smooth muscle L type calcium ion channel immunogenic peptide and application thereof, and belongs to the field of biotechnology and medicine. The immunogenic peptide has the following amino acid sequence: CGGPAEEDPS, CPAEEDPS, PAEEDPSGGC or PAEEDPSC, preferably CPAEEDPS. The vascular smooth muscle L type calcium ion channel immunogenic peptide containing a first binding site is coupled and combined with one or more carriers, preferably recombinant Qbeta-2aa phage virus-like particle protein to form ordered and repeated polypeptide-carrier vaccine. The invention discloses application of the vaccine to treatment of primary hypertension. The vaccine can produce high-efficiency specific antibody against the vascular smooth muscle L type calcium ion channel immunogenic peptide. The antibody can be used for effectively obstructing an L type calcium ion channel, so that the blood pressure of a spontaneously hypertensive rat can be obviously reduced.

0/0