The invention discloses a novel tetrammine palladium sulphate (II) synthesis method, comprising the following steps that: palladium chloride (PdCl2) reacts with ammonia water to generate tetraammine dichloropalladium (II); and tetraammine dichloropalladium (II) reacts with silver sulfate to generate a compound of tetrammine palladium sulphate (II). The reaction operation is simple, the reaction yield is high and more than 90%, and the purity of products is high and more than 99.0%.