A method for sorting and comprehensively utilizing municipal solid waste includes steps of: 1) feeding the municipal solid waste into a feeding tank through a feeding inlet, then outputting into a breaking device; 2) breaking refuse bags and large blocks by the breaking device; 3) transporting broken refuse into a two-stage roller screen for screening out dusts with a particle size of less than 3 mm, and hanging strips; and 4) transporting mixed refuse screened by the two-stage screen into a vibrating screen; screening oversize products by a heavy winnowing machine for separating inorganic blocks, large plastics and paper; transporting underflow products into a two-room multi-functional winnowing machine for dividing into heavy materials, light materials and medium materials. By effectively combining sorting devices, effective sorting and reutilization of mixed refuse are achieved. Thereafter, paper, fibers, plastics and kitchen organic refuse are respectively for producing refuse derived fuel, wood-plastic composite and fertilizer.