The invention discloses a fluoxetine hydrochloride liposome solid preparation and a preparation method of the fluoxetine hydrochloride liposome solid preparation. Active ingredients fluoxetine hydrochloride and egg yolk phosphatidyl glycerol, dimyristoyl phosphatidyl choline, cholesterol succinate and span 40 in specific combination are prepared into lipidosome, the stability, the dissolvability and the bioavailability of medicine are greatly improved, in addition, the effect is stable and durable, and the curative effect is obvious. The preparation disclosed by the invention has the advantages that the product quality of the preparation is improved, and the toxic or side effect is reduced.