The invention discloses a composition used for inhibiting bacteria generating novel beta lactamase. The composition is advantaged in that the active components of the composition comprise cefepime and tazobactam with a weight ratio of 2-6:1. According to the invention, the composition used for inhibiting the bacteria generating novel beta lactamase has a good inhibiting and/or killing effect against the bacteria generating novel CTX-M enzyme and AmpC enzyme, and is especially effective against bacteria with drug resistance to CTX-M enzyme and AmpC enzyme hydrolysis effects. The composition has good practicality, and provides good economic and social effects.