The invention discloses a preparation method of a high-ferrum low-silicon vanadium-titanium sintering ore, comprising the following steps of: granulating a sintered raw material, then sequentially carrying out material distribution and compression and sintering on the sintered raw material, wherein the sintered raw material contains iron ore concentrates, fuel, solvents and boron-containing substances, the granularity of the fuel is less than or equal to 3 mm, the fuel with the granularity less than 0.5 mm is 25-40 percent by weight accounting for the fuel, the sintering alkalinity of the sintered raw material is 2-2.5 according to the content of the solvents, the thickness of a material layer is 660-750 mm according to the material distribution, the ignition temperature of sintering is 1100-1150 DEG C, and the ignition time of the sintering is 2-2.5 minutes. The preparation method can enhance the strength and the finished product rate of the high-ferrum low-silicon vanadium-titanium sintering ore, improve the low-temperature reduction degradation performance and increase the output of the high-ferrum low-silicon vanadium-titanium sintering ore.