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发明公开
CN102766181A 6-O-取代的红霉素衍生物的制备方法 无效 - 撤回

6-O-取代的红霉素衍生物的制备方法
摘要：
本发明涉及6-O-取代的红霉素衍生物的制备方法技术领域。本发明所说的6-O-取代的红霉素衍生物(V)的制备方法，是在强碱作用下，式(VI)红霉素衍生物化合物与3-(3-喹啉基)-2-丙烯-1-卤代物反应：本发明提供的6-O-取代的红霉素衍生物(V)新制备方法，通过一步反应即很方便的得到式(V)红霉素衍生物化合物，条件容易控制，操作简单，适合工业化大规模生产。
摘要（英）：

The invention relates to the technical field of a preparation method of a 6-o-substituted erythromycin derivative. According to the preparation method of the 6-o-substituted erythromycin derivative, under the action of strong base, a erythromycin derivative compound as shown in the formula (VI) reacts with 3-(3-quinolyl)-2-propenyl-1-halide. By the adoption of the novel preparation method of the 6-o-substituted erythromycin derivative (V), the erythromycin derivative compound as shown in the formula (V) can be conveniently obtained by one-step reaction. The condition is easy to control. In addition, the preparation method is simple to operate and is suitable for industrial production at large scale.

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