The invention discloses an ore benefication process for low-grade fine particle grade embedded distribution refractory iron ore. The process comprises the following steps that crushed ore products are firstly subjected to one-stage ore grinding and one-stage grading, underflow after the grading is returned for re-grinding, and overflow is subjected to two-stage grading; underflow after the second-stage grading is subjected to second-stage ore grinding, ore grinding discharge materials are returned to the second-stage grading, and overflow is subjected to one-stage desliming; underflow after the desliming is subjected to three-stage grading and three-stage ore grinding, ore grading discharge materials are returned to three-stage grading, and overflow is subjected to second-stage desliming; next, three-section, four-section or five-section or more-section desliming is sequentially carried out; underflow after the desliming starts to be subjected to reverse flotation after the stirring, rougher flotation is firstly carried out, products in a groove after the rougher flotation are subjected to fine selection, foam products after the fine selection are returned to a rougher flotation groove, and products in a groove after the fine selection are concentrated and filtered to obtain ore concrete; and concentration machines and selective flocculation desliming processes are respectively adopted for each stage of desliming. The process provided by the invention has the advantages that the investment cost is low, the occupied area is small, the production and the maintenance are simple and convenient, the adaptability is high, the fine grinding desliming effect is good, and the like.