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发明公开
CN102836430A 阻断型抗体T5E3在逆转肿瘤多药耐药中的应用 有权

阻断型抗体T5E3在逆转肿瘤多药耐药中的应用
摘要：
本发明提供TRPC5的阻断型抗体T5E3的一种新用途，即：TRPC5的阻断型抗体T5E3在逆转肿瘤多药耐药中的应用，所述阻断型抗体的制备方法为：以人工合成或基因表达获得的E3肽段作为抗原并免疫动物制得，所述肿瘤多药耐药是由P-gp介导产生。本发明的重要之处是发现了TRPC5与肿瘤多药耐药密切相关，能间接上调介导肿瘤产生多药耐药的P-gp蛋白在多药耐药肿瘤细胞中的表达水平，以及TRPC5阻断型抗体T5E3对体内外肿瘤细胞的多药耐药具有明显的逆转作用，且对实验动物无毒副作用，因此，本发明为肿瘤多药耐药的逆转提供了新的思路，本发明阻断型抗体T5E3是一种具有良好开发前景的肿瘤多药耐药逆转剂。
摘要（英）：

The invention provides the novel application of the blocking antibody T5E3 of the TRPC5, particularly the application of the blocking antibody T5E3 of the TRPC5 to the reversing of tumor multidrug resistance. The blocking antibody is prepared by using the E3 peptide fragment which is obtained by artificial synthesis or gene expression as an antigen to immune an animal. The tumor multidrug resistance is generated by the mediation of P-gp (p-glycoprotein). The invention is characterized in that: the close relation of the TRPC5 and the tumor multidrug resistance is found, and the expression level of the P-gp for the tumor to generate the multidrug resistance in the multidrug resistance tumor cell can be indirectly increased and mediated. The blocking antibody T5E3 of the TRPC5 has the function of reversing the multidrug resistance of the tumor cells in vivo and vitro significantly and can not cause toxic and side effects to the experimental animal. The invention provides a novel idea for reversing the tumor multidrug resistance. The blocking antibody T5E3 is a tumor multidrug resistance reversing agent with good development prospect.

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