The invention discloses a device and method for hierarchical coordination control on the continuous flat pressing thickness of a medium density fiberboard, and belongs to the field of machinery equipment control. The device comprises a hot press plate and hydraulic cylinders arranged at the top end of the hot press plate, wherein the 25 hydraulic cylinders are arranged in a 5*5 array; displacement sensors and pressure sensors are configured on the hydraulic cylinder in the second row and the second column and the hydraulic cylinder in the second row and the fourth column; and only the pressure sensors are configured on the rest of the hydraulic cylinders. The method comprises the steps as follows: setting the thickness of a plate billet and the output displacements of the hydraulic cylinders in the second row and the second, third and fourth columns, changing a self-coordination mode, changing a mutual-coordination mode, and adjusting the outputs of the hydraulic cylinders in the first, third and fifth columns. By using the device and the method, the fixed thickness of the plate billet can be effectively controlled at the fixed thickness section of a continuous flat pressing machine, and the product quality is guaranteed.