The invention relates to a 4-(substituted phenylamino)quinazoline derivative and a preparation method, a pharmaceutical composition and application thereof. Specifically speaking, the invention relates to a compound as represented by formula I and a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2 and R3 in the formula I are defined in the specification. The invention also relates to the preparation method for the compound represented by formula I, the pharmaceutical composition of the compound and application of the compound in preparation of medicines used for treating and/or preventing diseases or symptoms related to receptor tyrosine kinases for mammals (including human beings). The compound represented by formula I in the invention is an effective irreversible inhibitor for tyrosine kinases.