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发明公开
CN103153337A 黏膜佐剂组合物 无效 - 驳回

黏膜佐剂组合物
摘要：
本发明公开了一种新型黏膜佐剂组合物。本发明的黏膜佐剂组合物至少含有从支气管炎博德特氏菌的菌体或其培养液得到的分子量为100kDa至300kDa的组合物。通过将该黏膜佐剂组合物用于非人动物等的黏膜面，可增强黏膜面的免疫能力。因此，例如，通过将本发明的黏膜佐剂组合物与经黏膜感染症灭活疫苗接种于非人动物等的黏膜面，可增强对经黏膜感染症的预防效果。本发明能有效预防诸如犬副流感病毒、犬腺病毒、犬冠状病毒、犬细小病毒、犬瘟热病毒、犬疱疹病毒、呼肠孤病毒、肺炎病毒中的其中一种或多种引发的经黏膜感染症。
摘要（英）：

Provided is a mucosal adjuvant composition containing at least a composition with a molecular weight of 100 - 300 kDa obtained from Bordetella bronchiseptica cells or a culture medium thereof. Immunity on a mucosal surface can be increased by administration of this mucosal adjuvant composition on the mucosal surface in nonhuman animals and the like. Therefore, for example, by administering an inactivated vaccine for a transmucosal infectious disease and this mucosal adjuvant composition to a mucosal surface in a nonhuman animal or the like, the prophylactic effect on the transmucosal infectious disease can be increased. The present invention is effective in preventing transmucosal infectious diseases including, for example, any of canine parainfluenza, canine adenovirus, canine coronavirus, canine parvovirus, canine distemper virus, canine herpesvirus, reovirus, and pneumovirus or a plurality of infections.

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