The invention relates to the field of Mg-Ca-containing refractory materials, in particular to a Mg-Ca-Zr-Ti brick for a cement kiln and a preparation method of the brick; the Mg-Ca-Zr-Ti brick for the cement kiln is characterized by comprising the following raw materials by weight percent: 95-99% of synthesized Mg-Ca sand, 1-5% of electric smelting stable zirconium oxide, 1-3% of titanium dioxide and bonding agent, wherein the weight of the bonding agent accounts for 2-5% of the total weight of the three raw materials, and paraffin is adopted as the bonding agent. The preparation method of the brick has the technological process steps of: preparing the raw materials, blending, mixing, drying, molding by pressing and sintering and is characterized in that the sintering temperature is between 1520 DEG C and 1570 DEG C. Compared with the prior art, on the premise that the advantages of a magnesite-dolomite brick are maintained, the Mg-Ca-Zr-Ti brick effectively overcomes the disadvantages of the conventional magnesite-dolomite brick, such as thermal shock resistance and high hydration rate; and the Mg-Ca-Zr-Ti brick has the characteristics of good thermal shock resistance and good hydration resistance, and can be used for replacing a magnesite-chrome brick used for a cement kiln burning zone, thus realizing non-chromium characteristic of the refractory brick for the cement kiln.