The invention relates to a manual multi-purpose drilling device which is characterized in that a handle and a drill pipe are connected, the drill pipe (2) is connected with a safety coupler through a flat key, the upper edge of an internal spiral rotating drum is connected with the safety coupler through a flange, and the inner spiral rotating drum is connected with an outer sleeve through threads. An annular retainer ring is arranged between the drill pipe and the internal spiral rotating drum, wherein a center hole of the annular retainer ring is sleeved on the drill pipe in a fixed-connection mode, the annular retainer ring makes contact with the lower edge of the internal spiral rotating drum in a sliding mode, and the drill pipe is connected with a drill bit chuck through threads. Two double-head screw rods (8) are arranged in sliding chutes in the two ends of a supporting plate (10) respectively, the lower ends of the double-head screw rods are connected with frame-shaped clamping plates (11) through threads, and bosses at the lower ends of the double-head screw rods are arranged in bowel-shaped sleeves. The supporting plate (10) and the outer sleeve (6) are arranged coaxially and movably connected through flat keys. By using of the device, in the whole process of manual drilling, only one action of rotating the drill pipe is needed to finish the manual drilling, through reference to scale marks on the drill pipe, the accurate drilling can be achieved, and replaceable clamping frames can be flexibly used in kinds of drilling places.