The invention discloses a large-stroke micro-drive precise two-dimensional worktable which is mainly composed of a base, an X-direction feeding device, a Y-direction feeding device and a feeding device top worktable surface, wherein the X-direction feeding device and the Y-direction feeding device are mutually perpendicular in a two-dimensional plane, the Y-direction feeding device is arranged above the X-direction feeding device, the X-direction feeding device comprises an X-direction large-stroke feeding device and an X-direction micro-feeding device, the Y-direction feeding device comprises a Y-direction large-stroke feeding device and a Y-direction micro-feeding device, and the Y-direction large-stroke feeding device is arranged above the X-direction micro-feeding device and can move along with feeding motion of the X-direction micro-feeding device. A transition connecting plate of the base is connected with a machine tool. Due to the fact that fine precision drive of the worktable is matched with large-stroke displacement output, output force is large, the resolution ratio of displacement is high, the range of the displacement is large, and the large-stroke micro-drive precision two-dimensional worktable has a wide application prospect. Due to cooperation of a cooling system, the large-stroke micro-drive precision two-dimensional worktable avoids the machining difficulty that the feeding precision is influenced by heat generated by long-time precise machining and heating.