The invention discloses a measurement control system of a multi-shaft support air floatation platform and belongs to the technical field of ultraprecise apparatus platforms. The measurement control system aims to solve the problem that existing support platforms are limited in leveling conditions and narrow in application range. The measurement control system comprises a load feedback unit, an executing unit, a position measuring unit, a safety protecting unit, a controller, a rotating motor and a straight-light source, the load feedback unit comprises M pressure sensors and four differential sensors, the executing unit comprises M servo voice coil motors and M servo voice coil motor drivers, the position measuring unit comprises a plane grating, M straight gratings, a linear-array CCD (charge coupled device) formed by at least six CCDs, a tilt angle sensor, M electronic level meters and an indoor GPS (global positioning system), and the safety protecting unit comprises 2M proximity sensors and M temperature sensors. The measurement control system is used for measurement controlling of the air floatation platform.