The invention relates to a transformer cooling system control strategy and method. The transformer cooling system control strategy and method is provided according to the actual measuring results of top layer oil temperature, bottom layer oil temperature, environment temperature, cooler inlet oil temperature and cooler outlet oil temperature of a transformer and the operating condition of transformer operating time parameters, and the internal temperature of the transformer is reduced by controlling starting and stopping of a cooler. The method can effectively carry out transformer cooling system control according to multiple influence factors, the operating condition of the transformer body and external environment influences, and therefore the effect of avoiding failures occurring to the interior of the transformer or acceleration of insulation aging caused by high temperature is achieved.