The invention belongs to the technical field of structural engineering, and relates to a multi-story high-rise fabricated steel structure framework supporting system. The multi-story high-rise fabricated steel structure framework supporting system is formed by assembling fabricated floor slabs, fabricated supports and fabricated flange columns through bolts. The fabricated floor slabs comprise slabs A, slabs B and slabs C, and the fabricated floor slabs are spliced through the bolts to form the whole layer of slabs of a building. The steel structure system combines modularization, factorization and assemblage to realize industrialized production and rapid site assembly, increase construction speed, reduce the construction period and reduce construction costs. Meanwhile, the steel structure system completely adopts high-strength bolts for site assembly to avoid environmental pollution caused by concrete pouring and steel welding. When structural members are dismantled, the structural members can be recycled in a mode of high efficiency, so that the construction waste is reduced, and the concept of green environmental protection is truly realized. The structure system is a green structure system.