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发明公开
CN103408653A 一种仿生防龋多肽及其制备方法和用途 有权

一种仿生防龋多肽及其制备方法和用途
摘要：
本发明公开了一种仿生防龋多肽、制备方法和应用。该防龋多肽包含如SEQIDNO.1或SEQIDNO.2所示的氨基酸序列及其盐或酯。本发明的仿生防龋多肽多肽主要包含具有HA结合特性的“HA6-1(SVSVGMKPSPRP)”氨基酸序列及可以诱导早期龋再矿化的“QPX”的氨基酸序列，还可以包含能够与钙离子作用并引发HA成核的氨基酸序列“TKREEVD”。该多肽分子量较小，可提高在牙釉质表面的吸附，进而更好地发挥其作用，促进早期脱矿牙釉质（早期龋）的再矿化，合成方便，经济实惠，效果较好且安全可靠。
摘要（英）：

The invention discloses a biomimetic anti-caries polypeptide and its preparation method and use. The invention discloses the biomimetic anti-caries polypeptide and its salt or ester. The biomimetic anti-caries polypeptide has an amino acid sequence shown in the formula of SEQ ID NO.1 or SEQ ID NO.2. The biomimetic anti-caries polypeptide mainly contains the amino acid sequence HA6-1 (SVSVGMKPSPRP) having the HA combination feature and the amino acid sequence QPX inducing early-stage caries remineralization, and can also contain the amino acid sequence TKREEVD acting on calcium ions and causing the HA nucleation. The biomimetic anti-caries polypeptide has small molecular weight, can improve absorption on the surface of enamel, can exert its effect better, can promote remineralization of early demineralized enamel (early decayed tooth), can be synthesized conveniently, and has good economical efficiency, good effects and high safety and reliability.

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