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发明公开
CN103524600A 新环脂肽抗生素罗克霉素（locillomycin）A、B、C及其制造方法 失效 - 权利终止

新环脂肽抗生素罗克霉素（locillomycin）A、B、C及其制造方法
摘要：
本发明涉及一组新环脂肽抗生素罗克霉素（Locillomycin）A、B、C及其制造方法，以罗克霉素A、B、C为活性成分的药物组合物以及罗克霉素A、B、C在制备抗真菌、细菌和病毒药物中的应用，所说罗克霉素A、B、C是由枯草芽胞杆菌Bs916菌株（Bacillus subtilis Bs916）培养物中分离得到的新环脂肽类抗生素（cyclic lipopeptides），体外活性实验结果证明，罗克霉素A、B、C对病原真菌、细菌和病毒都具有很强的抑制活性，作为新的抗真菌、细菌和病毒药物，具有良好的开发前景。
摘要（英）：

The invention relates to a group of new cyclic lipopeptides of locillomycins A, B and C and a preparation method thereof, a medicinal composition with active ingredients of locillomycins A, B and C, and an application of the locillomycins A, B and C in preparation of antifungal, antibacterial and antiviral medicaments. The locillomycins A, B and C are new cyclic lipopeptides separated from a culture of Bacillus subtilis Bs916 strains, and a result of an in vitro activity test proves that the locillomycins A, B and C have very strong inhibitory activity to pathogenic fungi, bacteria and viruses, are used as a new antifungal, antibacterial and antiviral medicament and have a good development prospect.

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