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发明授权
CN103626876B 细菌毒素疫苗 有权

细菌毒素疫苗
摘要：
使用植物细胞高效地生产志贺毒素蛋白质等的细菌毒素蛋白质。志贺毒素蛋白质等细菌毒素蛋白质是这样生产的：用含有下述DNA的DNA构建物转染植物细胞，使植物细胞生产上述细菌毒素蛋白质，所述DNA是编码介由具有以下特征（A）和（B）的肽而串联连接的杂化蛋白质的DNA，（A）氨基酸的个数为12～30个；（B）脯氨酸的含有率为20～35％。
摘要（英）：

A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.

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