The invention relates to a manufacturing method of a pomegranate wine. The method comprises the following steps: (1) carrying out a raw material pretreatment, adding pectase; (2) carrying out primary fermentation, putting pomegranate juice and grinded peel dreg into a fermentation container, adding active dry yeast and sulfur dioxide, carrying out fermentation for 3 to 5 days at a temperature of 200 to 260 DEG C; (3) separating so as to obtain the wine; (4) carrying out post fermentation; (5) clarifying, carrying out a clarification process on the pomegranate wine obtained by fermentation, filtering; (6) blending; (7) carrying out a freezing process for 3 to 5 days at a temperature of 50 to 70 DEG C, allowing the solid substances in the wine to fully precipitate, filtering; (8) carrying out a sterilization process on the base wine under a pressure of 200 MPa to 300 MPa at a room temperature, and finally carrying out aseptic loading. The method can maintain the original nutritional value and flavor of pomegranate.