The invention belongs to the field of health-care food, and particularly relates to conditioning composition for weight loss. The conditioning composition is prepared by taking natural plants as raw materials of water chestnuts, pineapples, konjac flour, grapefruit powder, kiwi fruit and newtol. The regulation composition for weight loss comprises the natural plants, contains appropriate dietary fiber, various essential vitamins and trace elements for a human body and has efficacy of losing weight, lubricating intestines, relaxing the bowels, restraining appetite, removing grease, reducing pressure, helping digestion, beautifying and protecting skin and the like; and the raw materials are easy to obtain, the preparation is simple, the taste is good, and the composition is convenient to take.