The invention discloses a method for determining a consumption difference analysis optimized target value system of a circulating fluidized bed unit. The method comprises the steps of clustering collected sample operation parameters by using a K-means algorithm to obtain K data clusters; selecting a data cluster with the minimum arithmetic mean value according to the arithmetic mean value of each data cluster; and then determining a parameter corresponding to a clustering center of the selected data cluster as an optimized target value. Due to the adoption of the method for determining the consumption difference analysis optimized target value of the circulating fluidized bed unit, the real-time performance and the accuracy are improved; the complex calculation amount and test cost can be reduced; and manpower and material resources are greatly saved. The method for determining the consumption difference analysis optimized target value system of the circulating fluidized bed unit can be widely used in the field of consumption difference analysis of power stations.