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发明公开
CN103751145A 一种均匀性改善的奥硝唑胶囊 无效 - 撤回

一种均匀性改善的奥硝唑胶囊
摘要：
本发明提供了一种均匀性改善的奥硝唑胶囊，包括奥硝唑20-30％，填充剂20-45％，崩解剂6-12％，粘合剂、润滑剂适量。所述填充剂选自乳糖、蔗糖、葡萄糖、甘露醇、山梨醇、硫酸钙、葡萄糖酸钙、磷酸氢钙、淀粉、羧甲基淀粉、预胶化淀粉、微晶纤维素、糊精。所述崩解剂选自交联聚乙烯吡咯烷酮、预胶化淀粉、微晶纤维素、海藻酸、羟甲基淀粉钠。本发明均匀性改善的奥硝唑胶囊的制备方法包括以下步骤：将奥硝唑与填充剂、崩解剂、粘合剂充分混合，制成湿颗粒，经流化床干燥，过18目筛，加入0.5％硬脂酸镁，压片，粉碎后过14目筛，灌装胶囊，即得。
摘要（英）：

The invention provides an ornidazole capsule with improved uniformity, and the capsule includes 20-30% of ornidazole, 20-45% of a filler, 6-12% of a disintegrating agent, an adhesive and a proper amount of lubricant. The filler is selected from the group consisting of lactose, sucrose, glucose, sorbitol, mannitol, calcium sulfate, calcium gluconate, calcium hydrogen phosphate, starch, carboxymethyl starch, pregelatinized starch, microcrystalline cellulose and dextrin. The disintegrating agent is selected from the group consisting of cross-linked polyvinylpyrrolidone, pregelatinized starch, microcrystalline cellulose, alginic acid and sodium carboxymethyl starch. A preparation method of the ornidazole capsule with improved uniformity provided by the invention comprises the following steps: fully mixing ornidazole with the filler, disintegrating agent and adhesive, preparing the mixture into wet particles, drying by a fluidized bed, sieving through a screen of 18 mesh, adding 0.5% of magnesium stearate, tabletting, crushing, sieving through a screen of 14 mesh, and filling into capsules to obtain the ornidazole capsule.

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