The invention discloses a flue-curing process method capable of reducing protein content in the flue-cured tobacco. The process method disclosed by the invention is implemented according to the following steps of: A, preparing the flue-cured tobacco and placing the flue-cured tobacco into flue-curing equipment; B, sequentially carrying out six continuous flue-curing stages comprising four short-time flue-curing stages and two long-time flue-curing stages in the flue-curing process of the flue-cured tobacco; C, after flue-curing, obtaining the flue-cured tobacco with low protein content. According to the invention, on the premise of ensuring quality of the flue-cured tobacco, the step of controlling the content of a protein which is an important nitrogen-containing compound is migrated to the tobacco leave modulating stage, so that the flue-curing process method is helpful for improving chemical quality of tobacco leaves, and thus, damage of smoking to health of human bodies is further reduced. By the process conditions of the flue-curing process method, compared with a flue-cured sample in a conventional method, the flue-cured tobacco leaves has the advantages that the appearance quality, the proportion of medium-class and first-class tobacco and the smoking quality are all improved and the release amount of the protein is reduced by 15 percent to 25 percent.