The invention provides a two-moving one-rotation three-freedom complete decoupling space parallel connection mechanism, which comprises a fixed platform, a movable platform and three branches, wherein the three branches are connected with the fixed platform and the movable platform, the fixed platform is a rectangular bottom surface, two sides of the bottom surface of the fixed platform are provided with slide rails, the center line of each slide rail is parallel to the bottom surface of the fixed platform, the movable platform is of a triangular structure, the first branch consists of one moving pair, three rotating pairs and three connecting rods connected with the moving pair and the three rotating pairs, the second branch consists of four rotating pairs and three connecting rods connected with the four rotating pairs, and the third branch consists of one moving pair, four rotating pairs and four connecting rods connected with the moving pair and the four rotating pairs. The two-moving one-rotation three-freedom complete decoupling space parallel connection mechanism has the advantages that the structure is simple, the manufacturing cost is low, the two-moving effect of the movable platform in the direction being parallel to the fixed platform and the one-rotating effect around the axial line parallel to the fixed platform can be realized, each movement is completely decoupled, the control is easy, and the carrying force is strong.