The invention belongs to the field of pharmaceutical chemicals, and relates to an indazole-substituted pyrimidine derivative represented by formula I, and its pharmaceutically acceptable salt, a solvate of the derivative, or a solvate of the salt. The above compounds are effective tyrosine kinase inhibitors. The invention also relates to a preparation method of the indazole-substituted pyrimidine derivative, a medicinal composition containing the indazole-substituted pyrimidine derivative, its pharmaceutically acceptable salt, the solvate of the derivative or the solvate of the salt, and a use of the indazole-substituted pyrimidine derivative, its pharmaceutically acceptable salt, the solvate of the derivative or the solvate of the salt in the preparation of medicines for treating or adjunctively treating the proliferation and migration of tyrosine kinase mediated tumors or tyrosine kinase driven tumor cells in mammals (comprising human).