The invention provides a compound shown as the structural formula I, a preparation method and application thereof. The compound has polypide paralysis and insecticidal effects, can be used for preparing anti-schistosomiasis drugs, and overcomes poor curative effect or ineffective treatment phenomenon for the reason of drug resistance caused by long-term use of the anti-schistosomiasis drugs in the prior art. The compound has the advantages of simple structure and easy preparation.