The invention belongs to the technical field of construction of steel structures, and particularly relates to a manufacturing, installation and pre-deformation method for a large-span spatial special-shaped steel structure. The manufacturing, installation and pre-deformation method particularly comprises the following steps that a calculation model is built; pre-deformation load conditions are determined; three-dimensional deformation values of all nodes are obtained; a three-dimensional model after first-time pre-deformation is built; deformation difference values of the nodes are extracted, and comparison and analysis are conducted; according to the range of the difference values, a pre-deformation adjustment value is further determined; finally, the structure is installed. The manufacturing, installation and pre-deformation method is simple, convenient to implement and effective for manufacturing and installation of the spatial special-shaped steel structure, so that the appearance of the spatial special-shaped steel structure is the same as an initial target appearance set by the design is guaranteed.