The invention discloses a thin-wall safe with high prying resistance. The thin-wall safe with high prying resistance comprises a box, an electronic lock and a door panel assembly, wherein the door panel assembly comprises a door panel; the door panel comprises two groups of oppositely arranged side edges, and one group of side edges are a hinge connected side edge and a locking/unlocking side edge; the hinge connected side edge is hinged to the box; the locking/unlocking side edge is locked with or unlocked from the box through the electronic lock; in the other group of side edges of the door panel, a first prying resistant structure is arranged between each side edge and the box, and a second prying resistant structure is arranged between the hinge connected side edge of the door panel and the box; the first prying resistant structures and the second prying resistant structure are lug-clamping groove structures, and respectively comprise a lug and a clamping groove; when the door panel is locked with the box, each lug is just embedded in the corresponding clamping groove; when the door panel is opened abnormally, relative displacement between lugs and clamping grooves can prevent the lugs from being separated from the clamping grooves. Therefore, the reliable prying resistant structures I and II are arranged between the door panel and the box to fulfill the aim of preventing the safe from being opened by prying.