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发明授权
CN103988080B 用于腹主动脉瘤的生物标记物 有权

用于腹主动脉瘤的生物标记物
摘要：
本发明涉及检测个体的腹主动脉瘤AAA或对AAA的易感性的方法、监测个体的AAA的治疗功效的方法和评估个体的AAA的严重程度或AAA的风险的方法，所述方法涉及测量测试样品中存在的四氢生物喋呤H4B的量并且将其与标准物或先前测试样品中存在的H4B的量进行比较。所述测试样品中存在的H4B的量与所述标准物相比降低指示AAA或对AAA的易感性。可在第二时间点之前向所述个体投与治疗，且第二测试样品中存在的H4B的量与所述第一测试样品相比增加指示AAA的有效治疗。可鉴别出候选者用于进一步测试或监测AAA和/或治疗AAA。
摘要（英）：

Methods for detecting abdominal aortic aneurysm (AAA) or predisposition to AAA in a apoE subject, methods for monitoring the efficacy of treatment of AAA in a subject, and methods for evaluating the severity of AAA or risk of AAA in a subject involve measuring the amount of tetrahydrobiopterin (H4B) present in the test sample and comparing it to the amount of H4B present in a standard or previous test sample. A decreased amount of H4B present in the test sample compared to the standard is indicative of AAA or predisposition to AAA. Treatment can be administered to the subject prior to a second time point, and an increased amount of H4B present in the second test sample compared to the first test sample is indicative of effective treatment of AAA. Candidates can be identified for further testing or monitoring for AAA, and/or for treatment for AAA.

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