The invention relates to a high-altitude, high-lift, high-pressure pipeline and long-distance water conveying device and method. The high-altitude, high-lift, high-pressure pipeline and long-distance water conveying device comprises a water conveying pipeline (12). The high-altitude, high-lift, high-pressure pipeline and long-distance water conveying device is characterized in that the water conveying pipeline (12) is provided with a self-suction pump bottom valve (18), a self-suction pump (1), a filter (2), a vent valve (3), an inlet pressure transmitter (4), an inlet valve (5), an inlet pressure stabilizing device (6), an electric reciprocating pump (7), an outlet pressure stabilizing device (8), an outlet pressure transmitter (9), a check valve (10) and an outlet valve (11). The high-altitude, high-lift, high-pressure pipeline and long-distance water conveying device solves the high-altitude, high-lift, high-pressure pipeline water conveying problem under the severe physic-geographical environment at the DongChuan area, and the long service life of the water conveying device is guaranteed while enough large and stable water pressure can be provided through the arrangement of devices.