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发明公开
CN104047061A 抗日本血吸虫硫氧还蛋白谷胱甘肽还原酶SjTGR单区抗体及其制备方法 失效 - 权利终止

抗日本血吸虫硫氧还蛋白谷胱甘肽还原酶SjTGR单区抗体及其制备方法
摘要：
抗日本血吸虫硫氧还蛋白谷胱甘肽还原酶SjTGR单区抗体及其制备方法，属于生物技术的分子生物学、免疫学及药学技术领域。本发明提供了一种展示抗SjTGR蛋白的单区抗体的重组噬菌体展示库、抗SjTGR蛋白的单区抗体及其制备方法，所述的抗SjTGR单区抗体能与SjTGR蛋白特异性结合，和/或具有抑制SjTGR酶活性，可用于制备治疗血吸虫病的新药或治疗用药物的靶向载体。本发明为开发新的血吸虫病治疗药物及新的治疗方法奠定了良好的基础，对控制血吸虫病流行有重要的意义。
摘要（英）：

The invention relates to a schistosoma japonicum thioredoxin glutathione reductase Sj TGR single-domain antibody and a preparation method thereof, and belongs to the technical field of molecular biology, immunology and pharmacy of a pharmaceutical technology. The invention provides a recombinant phage display library for displaying an Sj TGR protein single-domain antibody, the Sj TGR protein resistant single-domain antibody and a preparation method thereof. The Sj TGR resistant single-domain antibody disclosed by the invention can be specifically combined with an Sj TGR protein and/or has Sj TGR inhibition activity and can be used for preparing a new drug for curing schistosomiasis or a targeting vector of the drug for cure. The schistosoma japonicum thioredoxin glutathione reductase Sj TGR single-domain antibody disclosed by the invention lays a good foundation for developing the new drug for curing the schistosomiasis and a new curing method and has important significance on controlling schistosomiasis prevalence.

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