The invention relates to a ternary nano composite drug, a preparation method thereof, and an application of the drug in preparation of a pharmaceutical composition for treating tumors. The ternary nano composite drug comprises a core carrier, an active pharmaceutical ingredient, and a stabilizing agent which is used to cover the core carrier and the active pharmaceutical ingredient. The core carrier comprises a first nano particle, which can generate active free radicals by supersonic wave excitation, a composite nano particle having medicinal imaging signals on the basis of the first nano particle, or a combination of the first nano particle and the composite nano particle. The pharmaceutical ingredient is loaded on the core carrier. The stabilizing agent comprises hydrophilic polymer, liposome with hydroxyl groups or carboxylic groups on the surface, bovine serum albumin nano particles, human serum albumin nano particles, or combination thereof. The invention also relates to an application of a binary nano composite drug in preparation of a pharmaceutical composition which can be used to cure tumors through supersonic wave excitation. The tumor target treatment can be realized through the synergetic cooperation between supersonic wave treatment and chemotherapy.