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发明公开
CN104087662A 对抗、预防和/或测定心力衰竭或心力衰竭的风险的工具和方法 无效 - 撤回

对抗、预防和/或测定心力衰竭或心力衰竭的风险的工具和方法
摘要：
本发明涉及用于诊断和/或预后受试者中的心力衰竭的方法，该方法包括下列步骤：测定获自所述受试者的体液样品中的至少一种遗传标志物的水平，其中所述至少一种遗传标志物是miRNA。本发明还涉及治疗或预防受试者中的心力衰竭的方法，该方法包括下列步骤：降低所述受试者中的至少一种miRNA的表达、数量和/或活性，或降低所述受试者中的至少一种miRNA与其mRNA靶标之间的相互作用，或增加所述受试者中的至少一种miRNA的mRNA靶标的表达、数量和/或活性。
摘要（英）：

The invention relates to a method for diagnosing and/or prognosing heart failure in a subject, the method comprising the step of determining the level of at least one genetic marker in a body fluid sample obtained from said subject, wherein said at least one genetic marker is an miRNA. The invention further relates to a method for treating or preventing heart failure in a subject, and the method comprising the step of decreasing within said subject the expression, amount, and/or activity of at least one miRNA, or decreasing within said subject the interaction of at least one miRNA with its mRNA target or increasing within said subject the expression, amount, and/or activity of the mRNA target of at least one miRNA.

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