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发明公开
CN104130348A 温度敏感型聚合物及原位凝胶化温度敏感型液体栓塞材料及其制备方法 无效 - 驳回

温度敏感型聚合物及原位凝胶化温度敏感型液体栓塞材料及其制备方法
摘要：
本发明涉及血管栓塞材料技术领域，特别涉及一种具有温度敏感特性的聚合物，是由N-异丙基丙烯酰胺与甲基丙烯酸丁酯共聚得到的。原位凝胶化温度敏感型液体栓塞材料，包括显影剂和温度敏感型聚合物。聚合物具有温敏特性，在病灶部位可以得到原位凝胶，避免栓塞时聚合物发散而导致的误栓；产品配方中所用溶剂为注射用水或生理盐水，无毒副作用，溶液状态，浓度低，流动性好；灭菌方法可以保持显影剂的显影效果。
摘要（英）：

The invention relates to the technical field of a blood vessel embolic material, and especially relates to a polymer with a temperature-sensitive feature. The polymer is obtained by co-polymerization of N-isopropylacrylamide and butyl methacrylate. The in-situ gelation temperature-sensitive liquid embolic material comprises a developer and the temperature-sensitive polymer. The polymer has the temperature-sensitive feature. With the polymer, in-situ gel can be obtained at a lesion site, and embolism error caused by polymer divergence during embolism can be avoided. The solvent used in a product formula is injection water or physiological saline with no toxic or side effect. The solvent is in a solution state with low concentration and good fluidity. A sterilization method helps maintaining a development effect of the developer.

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