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Invention Publication
CN104136612A 特异性结合CGRP的核酸 无效 - 撤回

特异性结合CGRP的核酸
Abstract:
本发明涉及能够结合CGRP的核酸分子，其中核酸分子包含中央核苷酸区段，其中所述中央核苷酸区段包含核苷酸序列5’HWn1n2YGGAn3An4UMn5n6Yn7n8n9n10n11Kn12Rn13ADn14n15ARn16Un17Cn18n19Un20n213’[SEQ ID NO:99],其中H、W、Y、G、A、U、M、B、K、R、D、C为核糖核苷酸并且n1为R或dG，n2为U或dT，n3为K或dG，n4为C或dC，n5为M或dC，n6为B或dU，n7为N或dG，n8为Y或dT，n9为N或dC，n10为R或dG，n11为V或dA，n12为K或dT或dU，n13为G或dG，n14为A或dA，n15为U或dT，n16为R或dG，n17为Y或dC，n18为C或dC，n19为B或dC，n20为C或dC，n21为C或dC，并且dG、dT、dC、dA和dU为2’-脱氧核糖核苷酸。
Abstract(English):

The present invention is related to a nucleic acid molecule capable of binding to CGRP, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5 ' HWn[1]n[2]YGGAn[3]An[4]UMn[5]n[6]Yn[7]n[8]n[9]n[10]n[11]Kn[12]Rn[13]And[14]n[15] ARn[16]Un[17]Cn[18]n[19]Un[20]n[21]3 ' [SEQ ID NO: 99], wherein H, W, Y, G, A, U, M, B, K, R, D, C are ribonucleotides, and n[1] is R or dG, n[2] is U or dT, n[3] is K or dG, n[4] is C or dC, n[5] is M or dC, n[6] is B or dU, n[7] is N or dG, n[8] is Y or dT, n[9] is N or dC, n[10] is R or dG, n[11] is V or dA, n[12] is K or dT or dU, n[13] is G or dG, n[14] is A or dA, n[15] is U or dT, n[16] is R or dG, n[17] is Y or dC, n[18] is C or dC, n[19] is B or dC, n[20] is C or dC, n[21] is C or dC, and dG, dT, dC, dA and dU are 2'-deoxyribonucleotides.

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