The invention provides a high-voltage transmission line in-river tower footing which comprises a steel pipe tower, a tower footing body and a protective fence. The steel pipe tower is arranged on the tower footing body, the protective fence is arranged on the periphery of the tower footing body, and the tower footing body comprises four bearing platforms, horizontal beam plates, cross beam plates and five pile columns. The four bearing platforms and the horizontal beam plates are sequentially connected at intervals to form a square whole, the cross beam plates are in cross shapes, and four ends of each cross shape are respectively connected with the corresponding bearing platforms. The four bearing platforms and cross points of the cross beam plates downwards extend to form the pile columns. The steel pipe tower is arranged on the tower footing body and supported on the four bearing platforms, the four bearing platforms are fixed through the horizontal beam plates and the cross beam plates, and materials can be saved under the condition that the strength requirement is met. The five pile columns play a good bearing role on the tower footing, and most of each pile column extends into the sediment to fix the tower footing and ensure the stability of the tower footing. The protective fence is arranged on the periphery of the tower footing body, the tower footing is simple in structure, and ships can be prevented from directly knocking the tower footing and the steel pipe tower.