The invention discloses a mechanical first-aid repair clamp for a pipeline and belongs to the technical field of pipeline maintenance and first-aid repair devices. An accommodating space is formed by an upper housing, a lower housing and a sealing assembly of the mechanical first-aid repair clamp, a pipeline leakage point is accommodated in the accommodating space, and the remaining space of the accommodating space is closed after the pipeline is accommodated in the accommodating space. Therefore, the mechanical first-aid repair clamp can be used for sealing the pipeline leakage point. A first set of integral zigzag slips for a first set of pipelines and a second set of integral zigzag slips for a second set of pipelines of the mechanical first-aid repair clamp can prevent relative motion between the inner walls of the slips and the outer walls of the pipelines, and the integral zigzag slips for the first set of pipelines and the integral zigzag slips for the second set of pipelines can further prevent relative motion between the outer walls of the integral zigzag slips and the inner walls of the housings. Therefore, the mechanical first-aid repair clamp can prevent the relative motion between the sealing mechanism and the outer walls of the pipelines when being applied.