The invention discloses an ink ribbon cassette and a printing apparatus. The ink ribbon cassette and printing apparatus capable of stably conveying an ink ribbon includes a supply shaft around which an ink ribbon is wound, a rewinding shaft around which the ink ribbon from the supply shaft is to be rewound, a guide shaft configured to abut the ink ribbon on a conveying path of the ink ribbon from the supply shaft to the rewinding shaft, and a regulation portion configured to abut the guide shaft according to a force applied to the guide shaft by the ink ribbon, thereby deforming the guide shaft to protrude toward the ink ribbon.