The invention discloses a method for cleaning and coating at least one surface of a container used for storing medicine or other ingestible non-medicinal products. The method comprises the step of adopting a water-based cleaning combination together with coating-containing water-based crosslinked acrylic resin. The cleaning and coating technologies based on the process conform to the current environmental regulations and workplace safety standards, and the process includes control over discharge of volatile organic compounds (VOCs). In addition, the concentration of organic compounds which can be separated out is lowered to the actual lowest level. The process can also be used for other base materials, and the process has the requirements that the amount of organic matters which can be separated out is low, and subsequently applied coating has high adhesiveness.