The invention discloses a ceramic-based manganese coating wire PCB. A substrate is ceramic, and the component of a coating wire is manganese. The invention also simultaneously discloses a preparation method of the ceramic-based manganese coating wire PCB. The method comprises the following steps: preparing a ceramic plate; generating a manganese coating wire layer on the ceramic plate by use of a thermal spraying method; trimming a coating wire layer by use of a CNC processing method; and cleaning a product. The ceramic-based PCB provided by the invention is quite low in cost and simple in production technology.