The invention discloses a medicine for treating wart diseases. The medicine is characterized in that the active component of the medicine comprises chloroquine as well as one or more of derivatives of chloroquine, wherein the active component accounts for 5-25% of the total weight of the medicine. The active component of the medicine has the characteristics of being wide in source of medicines, economic, cheap, convenient for external use, high in cure rate, free of relapse and obvious toxic and side effects and the like, can be used for eliminating HPV (human papilloma virus) and is suitable for treating various warts caused by HPV infection such as common warts, plane warts, verruca plantaris, condyloma acuminate and the like.