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CN104356013A 一种α-（N-甲基-N-苄胺基）-3-羟基苯乙酮盐酸盐的制备方法 无效 - 撤回

一种α-（N-甲基-N-苄胺基）-3-羟基苯乙酮盐酸盐的制备方法
摘要：
一种制备α-(N-甲基-N-苄胺基)-3-羟基苯乙酮盐酸盐的方法，包括：a)溴代反应：向3-乙酰氧基苯乙酮溶液中加入液溴、氧化剂进行溴代反应，制得α-溴-3-乙酰氧基苯乙酮；b)胺化成盐：在碱的存在下，所述α-溴-3-乙酰氧基苯乙酮与N-甲基苄胺反应，再经盐酸处理制得α-(N-甲基-N-苄胺基)-3-羟基苯乙酮盐酸盐。与已报道的方法相比，本发明的制备方法原料价廉易得，操作简便，成本低，产生的三废少。
摘要（英）：

The invention relates to a method for preparing alpha-(N-methyl-N-benzylamino)-3-hydroxyacetophenone hydrochloride, which comprises the following steps: a) bromination reaction: adding liquid bromine and an oxidizer into a 3-acetoxyacetophenone solution to perform bromination reaction, thereby obtaining alpha-bromo-3-acetoxyacetophenone; b) amination salification: in the presence of alkali, reacting the alpha-bromo-3-acetoxyacetophenone with N-methylbenzylamine, and treating with hydrochloric acid to obtain the alpha-(N-methyl-N-benzylamino)-3-hydroxyacetophenone hydrochloride. Compared with the reported methods, the preparation method provided by the invention has the advantages of cheap and accessible raw materials, low cost and fewer generated three wastes, and is simple to operate.

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