The invention provides a positioning device for a multi-angle anchor base plate. The positioning device comprises an anchor base plate fixing panel, a rubber strip, a clamping slot and an angle adjuster, wherein the rubber strip and the clamping slot are mounted on the periphery of the anchor base plate fixing panel; the angle adjuster is mounted at the bottom of the anchor base plate fixing panel; a fixing hole corresponding to a bolt hole in the anchor base plate is formed in the anchor base plate fixing panel; an operating hole for conveniently mounting a bolt is formed in the middle of the anchor base plate fixing panel; the angle adjuster comprises nuts, bolts and angle adjusting screw rods; the nuts and the bolts are mounted at four corners of the anchor base plate fixing panel; certain ends of the angle adjusting screw rods are in rotating connection with the nuts and the bolts. According to the invention, through the cooperation of the anchor base plate fixing panel and the angle adjusting screw rod, the position of the anchor base plate can be accurately positioned; the adjustment for the angle of a template can be easily realized through the rotation of the angle adjusting screw rod; compared with the prior art, the positioning device has the advantage that the template consumption is saved; the rubber strip on the periphery of the anchor base plate fixing panel can be tightly clung to a lateral baffle during a mounting process, so that the slurry leakage is effectively prevented and the forming quality of concrete on the anchor base plate is increased.