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发明公开
CN104368046A 一种纤维增强型载药水凝胶人工角膜裙边支架及其制备方法 失效 - 权利终止

一种纤维增强型载药水凝胶人工角膜裙边支架及其制备方法
摘要：
本发明属于人工角膜支架材料领域，提供了一种纤维增强型载药水凝胶人工角膜裙边支架及其制备方法，所述裙边支架由亲水性水凝胶、纤维和可生物降解载药微球组成，纤维的含量为6wt％～10wt％、可生物降解载药微球的含量为8wt％～15wt％、亲水性水凝胶的含量为75wt％～86wt％，所述纤维无序地分布在亲水性水凝胶中。该裙边支架具有水凝胶特有的优良生物相容性和渗透性，而且具有很高的抗拉强度，可生物降解载药微球释放出的药物能够缓解角膜移植术后炎症和并发症的发生。
摘要（英）：

The invention belongs to the field of keratoprosthesis stent materials and provides a fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent and a preparation method thereof. The skirt stent comprises the following components in percentage by weight: 6wt%-10wt% of fibers, 8wt%-15wt% of biodegradable drug-loading microspheres and 75wt%-86wt% of hydrophilic hydrogel, wherein the fibers are disorderedly distributed in hydrophilic hydrogel. The fiber-enhanced drug-loading hydrogel keratoprosthesis skirt stent has special excellent biocompatibility and permeability of hydrogel and very high tensile strength; the inflammations and complications occurring after the corneal transplantation can be relieved by virtue of drugs released by the biodegradable drug-loading microspheres.

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