The invention relates to the technical field of medicine and discloses an orally disintegrating tablet with functions of oral cavity paralysis and taste masking and a preparation method of the orally disintegrating tablet. The orally disintegrating tablet with the functions of oral cavity paralysis and taste masking comprises the following raw materials in percentage by weight: 40-80 percent of a medicine core, 10-50 percent of an auxiliary material absorbed with a taste masking agent, 5-30 percent of a disintegrating agent, 0-2 percent of a lubricating agent and 0-0.5 percent of an essence, wherein the taste masking agent is a water decoction formed by one or a combination of more of chili, black pepper and Sichuan pepper. The orally disintegrating tablet tastes good, has a spicy fragrance, and has a good taste masking effect; the taste masking effect on roxithromycin, norfloxacin and amoxicillin is extremely good by virtue of verification at present; by adding sesame oil and the essence, the stink of the amoxicillin can be well masked.