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发明授权
CN104398504B 一种去氧鬼臼毒素类药物的药物组合物及其制备方法和制剂 有权

一种去氧鬼臼毒素类药物的药物组合物及其制备方法和制剂
摘要：
本发明属于药物制剂领域，涉及一种含去氧鬼臼毒素类药物的药物组合物及其制备方法和制剂。一种含去氧鬼臼毒素类药物的药物组合物，该组合物包括去氧鬼臼毒素类药物和透明质酸‑5β胆烷酸，所述的透明质酸‑5β胆烷酸以胶束形式包裹去氧鬼臼毒素类药物。本发明还公开了药物组合物的制备方法和应用。本发明的药物良好的肿瘤靶向性，很好的安全性，降低毒副作用，提高疗效，可用于静脉注射，具有良好的应用，在肿瘤靶向性给药体系的研究以及肿瘤的治疗具有良好的应用前景。
摘要（英）：

The invention belongs to the field of pharmaceutical preparations, and relates to a deoxypodophyllotoxin medicine-containing pharmaceutical composition and a preparation method and a preparation thereof. The deoxypodophyllotoxin medicine-containing pharmaceutical composition comprises a deoxypodophyllotoxin medicine and hyaluronic acid-5 beta cholanic acid, and the hyaluronic acid-5 beta cholanic acid coats the deoxypodophyllotoxin medicine in micellar form. The invention also discloses the preparation method and application of the pharmaceutical composition. The deoxypodophyllotoxin medicine-containing pharmaceutical composition has excellent tumor targeting property and good safety, reduces the toxic and side effects, improves the curative effect, can be used for intravenous injection, and has good application prospect in tumor target drug application system research and tumor treatment.

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